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Biomarkers give hope for subset of patients
October 30, 2013
By: Gil Roth
President, Pharma & Biopharma Outsourcing Association
Merrimack Pharmaceuticals posted results of a global, Phase II, open-label, randomized study of MM-121 in combination with paclitaxel versus paclitaxel alone in patients with platinum-resistant or platinum-refractory advanced ovarian cancers. This study did not meet the primary endpoint of progression free survival (PFS) in the overall population. The hazard ratio (HR) for PFS was 1.0. Ongoing analysis of a pre-specified set of biomarkers mechanistically linked to ErbB3 signaling identified a p...
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